منابع مشابه
Simplified AKT Goes Cycling
Dr K.N. Mahajan is a recipient of Grant #W81XWH-12-1-0248 from the US Department of Defense. Dr N.P. Mahajan is supported by Grant #1R01CA135328 from the National Institutes of Health/ National Cancer Institute and Grants #W81XWH-14-1-0002 and #W81XWH-14-1-0003 from the Department of Defense. Protein kinase B (AKT) is an important signaling molecule in multiple cell types, relaying growth, prol...
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Nuclear intermediate filaments formed by A- and B-type lamins are central components of the nucleoskeleton and are required for the architecture and integrity of the nucleus. There is growing evidence that lamins are also involved in regulatory pathways controlling cell proliferation and differentiation. Lamins affect the activity of several transcription factors, such as retinoblastoma protein...
متن کاملAs iron goes, so goes disease?
The brain iron overload disorders, collectively known as neurodegeneration with brain iron accumulation (NBIA), would seem to be tantalizing targets for chelation therapy. Efforts to lower brain iron in these disorders date back to the 1960s with deferoxamine mesylate, but systemic iron depletion limited its use. With the advent of chelators better able to specifically relieve central nervous s...
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Motivated by recent developments in solid electrolytes based on lithium phosphorous oxynitride (LiPON) materials, we carried out computer simulations in order to develop an understanding of the detailed mechanisms of ionic transport. Starting with crystalline Li3PO4, we investigated some possible structures of isolated defects associated with extrinsic Li ion vacancies and interstitials. In par...
متن کاملAnything Goes
Representing OT hierarchies in terms of weighted sums of violations requires in the general case exponential growth of weights; and any such weight system will only work for finite fragments of grammars in which the quantity of violations incurred by optima does not grow without bound (typically, those fragments in which input size is bounded). This conclusion is based on a worst-case analysis,...
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ژورنال
عنوان ژورنال: Cancer Control
سال: 2014
ISSN: 1073-2748,1073-2748
DOI: 10.1177/107327481402100310